As a composer, Mitchell has been commissioned by the French Ministry of Culture, the Chicago Museum of Contemporary Art, Art Institute of Chicago, the Stone, the French American Jazz Exchange, Chamber Music America (New Works), the Chicago Jazz Festival, ICE, and the Chicago Sinfonietta. Mitchell has performed with creative music luminaries including Craig Taborn, Roscoe Mitchell, Joelle Leandre, Anthony Braxton, Geri Allen, George Lewis, Mark Dresser, Steve Coleman, Anthony Davis, Myra Melford, Bill Dixon, Muhal Richard Abrams, Ed Wilkerson, Rob Mazurek, and Billy Childs, and Hamid Drake. She is a recipient of the Herb Alpert Award (2011), the Chicago 3Arts Award (2011) , the Doris Duke Artist Award (2012) and the United States Artist Award (2020). Mitchell is a Professor of Music at the University of Virginia, and previously taught at University of California Irvine and the University of Pittsburgh.